Everything tirzepatide does, plus a third lever — glucagon — that raises metabolic rate. Phase 3 is complete and the topline numbers are the largest in the class. Here's the honest picture: the data, the dosing, the glucagon side effects, and how to order it research-grade now.
One paragraph on the molecule, one on why the third pathway matters. Both from the product page.
Everything tirzepatide does — appetite suppression — plus a third lever, glucagon, which turns up your metabolic rate. You burn more on top of the same appetite suppression. That's the entire 'next-gen' claim in one sentence.
GLP-1R/GIPR/GCGR co-agonism (the TRAILBLAZER program, Eli Lilly). Glucagon-receptor activation increases energy expenditure — thermogenesis — and modulates hepatic glucose output.
The figures verbatim from the retatrutide product page. This is the most advanced triple agonist in the pipeline.
Roughly 24% mean body-weight loss at 48 weeks at 12 mg, per Phase 3 topline. For context: semaglutide's STEP-1 ran −14.9% at 68 weeks and tirzepatide's SURMOUNT-1 −20.9% to −22.5% at 72 weeks.
Evidence grade B — the data is Phase 3, the approval isn't in yet (2026 watch). The most advanced 'triple agonist' in the pipeline, which is exactly the niche it's supplied for.
Typical research ranges from the product page — not a prescription.
| Step | Dose (weekly) | Note |
|---|---|---|
| Start | 4 mg | Entry step of the TRAILBLAZER arms. |
| Step 2 | 8 mg | Mid-curve. |
| Top | 12 mg | The arm that produced the ~24% @48wk topline figure. |
From the product page. The GI profile is class-typical; the heart-rate effect is the one to know about before you start.
Class-typical — similar to semaglutide and tirzepatide. The product page's own FAQ puts it at 'similar GI tolerability' to the dual agents.
This is the glucagon effect — a mild increase, noted in the product page FAQ. It's the honest price of the third pathway.
On the list, low frequency. Same category as the other agents in the class.
Per-vial pricing, two payment paths, same delivery as the rest of the range.
RT vials (5–15 mg × 10) support the full titration curve — order one vial or a full course, the per-vial price is the same.
Same lot, same delivery, whole order 10% off. Quote your order number as the payment reference.
Every batch ships with its Certificate of Analysis — tracked, insured, UK-wide, next working day dispatch. WELCOME10 stacks on your first order.
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