Cagrilintide + Semaglutide
A combination of the amylin analogue cagrilintide with the GLP-1 semaglutide — the 'next wave' combination studied after single-agonist monotherapy.
Also known as: Amylin + GLP-1 combination
Research context
- Combines amylin and GLP-1 signalling in a single research vial.
- Reflects the direction the clinical pipeline has moved.
- Available in 5mg and 10mg.
Related compounds
What cagrilintide + semaglutide is
This is a two-mechanism combination. Semaglutide is a GLP-1 receptor agonist — an incretin mimetic. Cagrilintide is a long-acting analogue of amylin, a hormone co-secreted with insulin by the pancreas that acts on amylin receptors in the hindbrain to influence satiety and gastric emptying.
The two pathways are complementary rather than duplicative: GLP-1 signalling and amylin signalling converge on appetite regulation through different receptor populations, which is why the pairing has been the subject of combination research rather than a single-agonist dose escalation. It is the direction the clinical pipeline has visibly moved.
The honest bound: a research vial combining two compounds is not the same article as the co-formulated clinical product studied in trials. Trials of a fixed-ratio combination use a specific, validated ratio and formulation; the contents of a research vial are not standardised to that ratio. Human outcome data applies to the clinical product, not to an arbitrary research mix.
Where it sits in the catalogue
All four of the incretin/amylin lines we stock, with their mechanisms, so the distinction is plain:
| Compound | Mechanism | Human evidence |
|---|---|---|
| Cagrilintide + Semaglutide | Amylin analogue + GLP-1 agonist (two pathways) | Combination has substantial clinical trial data as a fixed-ratio product |
| Semaglutide | GLP-1 receptor agonist | Extensive — approved medicine in many countries |
| Tirzepatide | Dual GIP / GLP-1 agonist | Extensive — approved medicine in many countries |
| Retatrutide | Triple GLP-1 / GIP / glucagon agonist | Late-stage trials; not yet an approved medicine |
The single-agonist lines are simpler to reason about; this combination is for research that specifically wants both arms active. If the aim is one well-characterised pathway, the monotherapy pages are the more direct choice.
Supply, handling and documentation
Supplied as lyophilised (freeze-dried) powder in sealed vials, 5mg and 10mg presentations, priced per vial.
- Lyophilised powder: store sealed, refrigerated, protected from light.
- Reconstituted solution: refrigerate at 2–8°C and keep covered.
- Peptide solutions are fragile: avoid repeated freeze/thaw cycles and vigorous agitation.
Batch documentation is available on request — see the lab and COA policy for exactly what is and is not provided, and the reconstitution guide for the method in detail.
Ordering, payment and delivery
Pricing is per vial, shown openly at the top of this page. Card checkout runs through Stripe. Bank transfer is offered at a 10% discount with prices shown under each card price; bank orders are confirmed once funds clear. UK dispatch is same or next working day, tracked.
Delivery times and payment details are set out in full on the delivery page. If anything is unclear before ordering, contact us — we would rather answer a question than process a return.
Cagrilintide + Semaglutide: common questions
Is this the same as the clinical combination product?
No. It is a research vial containing both compounds. The clinical combination product is a specific fixed-ratio, validated formulation; a research vial is not standardised to that ratio.
Is it a medicine?
No. It is supplied as a research chemical. It is not a medicine, it is not for human or veterinary use, and nothing on this page is medical advice.
Why combine amylin and GLP-1 rather than dose one higher?
Because they act on different receptor populations with complementary effects on appetite regulation, the pairing is studied as a way to engage two pathways rather than escalate one.
Which sizes do you stock?
5mg and 10mg vials, priced per vial. Both are listed in the price table above.
Does it need to be refrigerated?
Yes — sealed lyophilised vials should be refrigerated and kept out of light. Once reconstituted, keep at 2–8°C.
Do you provide a certificate of analysis?
Batch documentation is available on request. See the lab and COA policy for exactly what is provided and what is not.