AOD-9604
AOD-9604 is a modified fragment of human growth hormone studied for its effects on fat metabolism rather than growth.
Also known as: HGH fragment 177-191
Research context
- Fragment of HGH researched for lipolytic (fat-metabolising) activity.
- Studied separately from HGH's growth effects.
- Available in 5mg and 10mg.
What AOD-9604 is
AOD-9604 is a fragment of human growth hormone — amino acids 177 to 191 — modified so it keeps the lipolytic (fat-metabolising) activity in research models while shedding most of the growth-promoting activity of full-length HGH. It exists as a lyophilised peptide in 5mg and 10mg vials, and it is one of the most requested compounds in the weight-loss & metabolism research category. In this site's range it sits alongside MOTS-c and tesamorelin as the mechanism-focused side of fat research — the incretin class (retatrutide, tirzepatide, semaglutide, mazdutide) covers the appetite and total-weight side.
Where it sits in the weight-loss & metabolism category
The honest short version: AOD-9604 has the best preclinical fat story in the category and a weak human story. Its Phase 2/3 program in humans was terminated early and it was never approved for use, so every serious comparison in this space treats it as a hypothesis, not a proven compound. That makes it a research purchase in the truest sense of the phrase.
| Compound | What it's researched for | Human evidence |
|---|---|---|
| AOD-9604 | Direct fat mobilisation; HGH fragment 177-191 | Small, inconclusive; trial terminated early |
| Tesamorelin | Visceral fat reduction (GHRH agonist) | Approved for HIV lipodystrophy; Phase 3 + 2026 meta-analysis |
| Retatrutide | Total weight loss (triple agonist) | Large Phase 2/3 programmes |
| MOTS-c | Metabolic function, caloric restriction mimicry | Preclinical only |
The full category comparison — including where the incretin class takes the human-evidence lead — lives in our fat-loss peptide guide, which treats AOD-9604 head-on as the category's cautionary tale.
How it is supplied and handled
Vials are UK-held, lyophilised, and ship with the batch's certificate of analysis — HPLC purity and mass-spectrometry identity on every lot. Standard cold-chain handling from the warehouse; on arrival, reconstitute with bacteriostatic water per our reconstitution guide. Full lab and COA policy is on the COA page.
Ordering, payment and delivery
Card checkout runs on Stripe (prices on the right); bank transfer gets 10% off — the bank price is printed under each card price, and bank orders confirm once the transfer clears. UK dispatch; delivery details on the delivery page, anything else on contact.
Frequently asked questions
What is AOD-9604 actually?
A modified fragment of human growth hormone (amino acids 177-191) with lipolytic activity in research models and most of HGH's growth activity removed. Research purposes only.
Does AOD-9604 actually work?
The preclinical data are compelling; the pivotal human study was terminated early and it was never approved. Buy it for the research question, not on a human efficacy claim — that is the category's standing cautionary example.
AOD-9604 or tesamorelin for visceral fat research?
Tesamorelin carries the documented human evidence (approved indication, Phase 3 trials). AOD-9604 is the mechanism-focused option; stacks pairing both are common in research use, which is why the two pages cross-link.
What strengths do you stock?
5mg and 10mg lyophilised vials, UK-held, COA per batch. From £17.85 on card, 10% off by bank transfer.
How do I reconstitute it?
Standard bacteriostatic-water reconstitution; the full procedure, kit and handling are in our reconstitution guide, linked above.
Is AOD-9604 a medicine?
No — research chemical, supplied strictly for research purposes only. Not a medicine, not for human or veterinary use, and no dosing advice is given.