Kisspeptin-10
Kisspeptin-10 is a peptide studied as a key regulator of the reproductive hormone cascade, including its role in GnRH signalling.
Also known as: KISS1-derived peptide
Research context
- Central regulator of the GnRH (reproductive) axis.
- Researched in both male and female hormone studies.
- Available in 5mg and 10mg.
What kisspeptin-10 is
Kisspeptin-10 is the shortest fragment of the peptide encoded by the KISS1 gene that still carries full activity at its receptor, KISS1R (historically GPR54). The full-length product is cleaved down to a family of shorter peptides, and the 10-amino-acid form is the one most commonly used in research because it retains the receptor-binding region in a compact, practical sequence.
Its significance is positional rather than incidental. Kisspeptin signalling sits at the very top of the reproductive hormone cascade: it is the upstream input that governs gonadotrophin-releasing hormone (GnRH) release, which in turn drives the pituitary signal that regulates downstream reproductive hormones. Almost every other compound on our sexual-health shelf acts further down that chain.
Where it sits in the sexual-health category
Most research peptides in this category act on a downstream receptor or a local pathway — PT-141, for example, is studied through melanocortin receptors and a central pathway, not the gonadotrophin axis. Kisspeptin-10 is different: it is studied as a regulator of the axis itself, which makes it a reference point for questions about how the upstream control of reproductive hormone signalling works.
It is also one of the most intensively studied peptides in this class. The KISS1/KISS1R system has a broad published literature spanning receptor pharmacology, signalling biology and endocrine endpoints, so the compound carries a documented record rather than a folklore one.
Kisspeptin-10 vs other compounds in this category
| Compound | Receptor / class | Where it differs |
|---|---|---|
| PT-141 (bremelanotide) | Melanocortin-receptor agonist | Acts on a central melanocortin pathway rather than the GnRH cascade — a different upstream control system entirely. |
| GnRH / gonadorelin | GnRH-receptor agonist | Acts one step downstream of kisspeptin, directly on the pituitary. Kisspeptin-10 is studied as the input that regulates GnRH signalling in the first place. |
| Full-length kisspeptin-54 | KISS1R agonist | The longer parent peptide; the 10-residue fragment is the compact form most often used where the receptor-binding region is the focus. |
The practical takeaway: if the research question is about the upstream regulation of the reproductive hormone axis, kisspeptin-10 is the direct reference compound. If the question is about a downstream or central pathway, a different compound on the shelf is the better fit.
How it is supplied and handled
Kisspeptin-10 ships as a lyophilised (freeze-dried) powder in a sealed vial — the standard stable form for research peptides. It is available here in 5mg and 10mg vials. Once reconstituted with bacteriostatic water it should be kept refrigerated and handled cold-chain; the general reconstitution guide covers the volumes, the arithmetic and the storage handling that apply to this class of compound.
Every batch is supplied with a certificate of analysis. Our lab and COA policy explains what is tested and what the documentation covers — if you need a batch-specific COA before ordering, ask via the contact page and we will send it.
Ordering, payment and delivery
Pricing is per single vial — no minimum order and no bundle you have to take to get a sensible rate. Card checkout runs on Stripe; bank transfer is available at 10% off and confirms on clearance. UK dispatch is cold-chain, and delivery sets out the timelines and what to expect on arrival.
Common questions
What is kisspeptin-10?
It is the 10-amino-acid fragment of the peptide encoded by the KISS1 gene that retains full activity at the KISS1R (GPR54) receptor. It is studied as an upstream regulator of the reproductive hormone cascade through GnRH signalling.
Is kisspeptin-10 a research chemical or a medicine?
As sold here, it is a research chemical. It is not a licensed medicine in the UK, it is not for human or veterinary use, and nothing on this page is medical advice or a dosing recommendation.
What strengths do you stock?
5mg and 10mg vials. The 5mg is £8.50 and the 10mg is £16.15 per vial, with a 10% discount on bank transfer.
How is kisspeptin-10 different from PT-141?
PT-141 is studied through a central melanocortin pathway. Kisspeptin-10 is studied as an upstream regulator of the GnRH (reproductive hormone) axis — a different control system, and a different position in the cascade.
Is there a minimum order?
No. Pricing is per vial, so you can order a single vial or as many as you need.
Does it come with a COA, and how is it shipped?
Yes — a certificate of analysis accompanies every batch and is available on request before you order. It ships as lyophilised powder with cold-chain UK dispatch; see the delivery page for timelines.